12 Worst Side Effects of Amlodipine You Should NEVER Ignore

Amlodipine is a commonly prescribed medication used to treat high blood pressure (hypertension) and chest pain (angina). It belongs to a group of drugs called calcium channel blockers, which work by relaxing blood vessels so blood can flow more easily.

For most people, amlodipine is safe and effective. However, like all medications, it can cause side effects—some mild, others potentially serious. Certain symptoms should never be ignored, as they may signal a dangerous reaction that needs medical attention.

Below are the 12 worst side effects of amlodipine you should be aware of.

1. Severe Swelling (Edema) in Feet, Ankles, or Legs

Mild swelling is common, but sudden or severe swelling can indicate fluid retention or heart stress.

Never ignore if:

• Swelling worsens quickly

• One leg is more swollen than the other

• Swelling is painful or tight

2. Chest Pain That Gets Worse

Amlodipine is supposed to reduce chest pain—not increase it.

Warning signs:

• New chest pain after starting the medication

• Chest pain spreading to the arm, jaw, or back

• Chest pain with sweating or shortness of breath

➡️ This may indicate a heart problem and requires urgent care.